The International Maritime Organization(IMO) has promoted e-navigation strategies for the purpose of reducing marine accidents due to human errors and protecting marine environment. In accordance with the e-navigation strategy implementation plans, e-navigation SQA and HCD guideline was developed, and this was adopted as circular document of IMO in 2015. With the implementation of e-navigation strategies from 2018, e-navigation SQA and HCD guideline will be applied to marine systems and software developments. The e-navigation SQA and HCD guideline presents international standard-based procedures that can reflect human factors in e-navigation system and software developments and ensure software quality. The main quality that we want to achieve by applying SQA and HCD to system and software developments is usability. The usability is a main characteristic of software quality, and the usability evaluation is a method of assessing the results of application of the HCD principle. In this paper, the usability evaluation items of ISO 9241-11, the HCD related standards, and the usability metrics dealt with in ISO/IEC 25022 and 25023, the SQA related standards were analyzed and compared in order to help measure and evaluate the usability of the products developed by applying the e-navigation SQA and HCD guideline. ISO 9241-11 provides the usability evaluation items that can be applied to the entire system including software, and ISO/IEC 25022 and 25023 provide specific metrics for measuring the software usability. The results of a comparison between the usability metrics of ISO 9241-11 and the usability metrics provided by ISO/IEC 25022 and 25023 derived that the set of usability metrics for e-navigation. This is a core set of metrics that can be used for usability measurement regardless of the type of e-navigation system and software.