한국해양대학교

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다공성 세포지지체의 미시구조 모델링과 유효확산계수 예측

Title
다공성 세포지지체의 미시구조 모델링과 유효확산계수 예측
Author(s)
유수환
Keyword
Scaffold(세포지지체), Discrete element method(이산요소법), Effective diffusivity(유효확산계수), Particulate leaching(침출법)
Publication Year
2019
Publisher
한국해양대학교 대학원
URI
http://repository.kmou.ac.kr/handle/2014.oak/11896
http://kmou.dcollection.net/common/orgView/200000180722
Abstract
The scaffolds are used to regenerate the damaged tissues of cartilages and bones growing the patients’ cells. In particular, it is very important that the pores of scaffolds are connected to one another without interruption because they serve as channels for supplying oxygen or various nutrients required for cell growth to the tissue cells. To model the pores and their interconnectivity generated by leaching cubic salt particles, packing and compression processes of salt particles are simulated using the discrete element method. Based on the pore configurations obtained using the discrete element simulations, the domains through which the oxygen and nutrients flow are modeled and the diffusion analyses are then conducted to evaluate the scaffold performance in an indirect manner. The effect of the size and mass of salt on the scaffold is investigated by calculating one- and three-dimensional effective diffusivities. It is confirmed that a high diffusivity is obtained with a high level of pore connectivity, which would lead to good performance of cell growth.
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기계공학과 > Thesis
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