경도인지장애 노인의 Apo E genotype과 신체활동이 homocysteine, hs-CRP, plasma antioxidants 및 lipid profile에 미치는 영향

Abstract

The degenerative Alzheimer's disease(AD) gradually occur and progress, and mild cognitive impairment is clinically important as an indicator of AD. This study attempted to classify a mild cognitive impairment(MCI) group of 10 and another normal control(NC) group of 10 after MMSE tests and utilize Borg's scale of physical activity on which the aged over 65 participated in 'Uri Dance Gymnastics' with 12 to 14 intensity, twice a week, 120 minutes a day in the period of 12 weeks. Accordingly, repeated measured ANOVA(RM ANOVA), independent and paired t-tests at the significant level of a=.05 revealed following findings.

First, the most frequent Apo E genotypes included E3, E4 and E2 in order. In specific, E2 frequently occurred in NC but E4 in MCI.

Second, RM ANOVA revealed a significant effect of group factor on levels of Homocysteine. In specific, it was found that the MCI group had significantly higher levels of Homocysteine in both pre and post physical activity but levels of Homocysteine significantly decreased only in the NC group.

Third, RM ANOVA revealed a significant effect of group factor on levels of hs-CRP. However, following post-hoc tests indicated no significant effects of both physical activity and group factors.

Fourth, RM ANOVA revealed significant effects of group factor on levels of uric acid and Total bilirubin. The MCI group had significantly higher levels of uric acid but lower levels of Total bilirubin in both pre and post physical activity.

Fifth, a significant interaction effect was found in Total cholesterol and a significant decrease occurred only in the NC group. HDL-C had a significant group effect and the NC group had significantly higher levels of HDL-C. In addition, LDL-C had a significant interaction effect between physical activity and group factors but a significant difference occurred only in the NC group.

In conclusion, it is implied that the physical activity can generate positive effects on biochemical factors associated with AD. Therefore, it is expected that the aged over 65 with a high mobility rate of AD can benefit from participating in physical activities and physical activities can contribute to preventing degenerative diseases in the aged society.